Long-Lasting Plasticity of Hippocampal Adult-Born Neurons

Long-lasting plasticity of hippocampal adult-born neurons.

Adult neurogenesis occurs in the dentate gyrus of the hippocampus, which is a key structure in learning and memory. It is believed that adult-born neurons exert their unique role in information processing due to their high plasticity during immature stage that renders them malleable in response to environmental demands. Here, we demonstrate that, in rats, there is no critical time window for ex...

Culturing Adult Rat Hippocampal Neurons with Long-Interval Changing Media

Background: Primary cultures of embryonic neurons have been used to introduce a model of neurons in physiological and pathological conditions. However, age-related cellular events limit this method as an optimal model in adult neurodegenerative diseases studies. Besides, short-interval changing media in previous cultures decreases the effectiveness of this model. As an example of this matter, w...

culturing adult rat hippocampal neurons with long-interval changing media

background: primary cultures of embryonic neurons have been used to introduce a model of neurons in physiological and pathological conditions. however, age-related cellular events limit this method as an optimal model in adult neurodegenerative diseases studies. besides, short-interval changing media in previous cultures decreases the effectiveness of this model. as an example of this matter, w...

Long-lasting hippocampal plasticity: cellular model for memory consolidation?

Adult-born hippocampal neurons mature into activity-dependent responsiveness.

The mammalian hippocampus is a highly plastic brain structure in which new neurons are generated throughout adulthood. Do these new neurons qualitatively and quantitatively participate in the activity-dependent gene expression after challenging the hippocampus in a learning task? Adult mice were injected with bromodeoxyuridine (BrdU) to label dividing cells and indeed, individual BrdU-labelled ...